馬念涵
合聘教授

nianhan.ma@gmail.com
研究室: 教學204室
TEL: (03)4227151 ext 36112
FAX:

http://www.ncu.edu.tw/~ncu36113/ch.home.html

學歷
美國耶魯大學病理學博士

經歷
國立中央大學生醫所助理教授

學術專長
癌症生物學、訊息傳遞網路、藥物研發

目前研究方向
  1.癌症與幹細胞的訊息調控網路

    微型RNA (MicroRNAs)已被證明是轉錄後基因表現的主要調節者,
  微型RNA表現不正常也影響許多疾病的產生,微型RNA是為更有效率的分類依據。
  因此,微型RNA很有機會成為未來新穎疾病的指標,及用於疾病治療。
  我們利用高通量實驗方法去了解 微型RNA 與訊息傳遞網的相互調控關係,
  也藉此發展疾病治療新方法及偵測疾病新穎生物標記。

  2.中草藥用於與疾病藥物治療

    A. 開發中草藥品質控管的生物平台
    B. 分析中西藥併用的聯合分子機制
    C. 癌症化療併用減少副作用的機制
  3. EB病毒參與的疾病研究

獎項
  • 2014 Outstanding research award, National Central University
  • 2013 Excellent teaching award, National Central University, Taiwan

    著作
     
    1. Mok JA, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke G, Sheridan DL, Parker VD, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma NJ, et al. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Science Signaling, 2010, 3(109):ra12
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    2. Chiou YS, Ma N, Sang S, Ho CT, Wang YJ, Pan MH, Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. Journal of Agricultural and Food Chemistry 2012, 60 (13), 3441-3451
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    3. Wang CH#, Ma N# , Lin YT#, Wu CC, Hsiao M, Lu FL, Yu CC, Chen SY, Lu J. A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal. (# Co-First Author) Stem cells,2012, 30:2199–2211
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    4. Lee MF, Tsai ML, Chien LL, Cheng AC, Ma N, Ho CT, Pan MH, Phyto-Power dietary supplement potently inhibits dimethylnitrosamine-1 induced liver fibrosis in rats, Food & Function, 2013, 4(3):470-475
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    5. Chen Y-J, Thang M WC, Chan Y-T, Huang Y-F, Ma N, Yu AL, Wu C-Y, Hu M-L, Chiu K-P, Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma Cells, PLOS ONE, 2013, 8(12): e82751. doi:10.1371
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    6. Chung, FH, Chiang, YR, Tseng, AL, Sung, YC, Lu, J, Huang, MC, Ma, N*, Lee, HC*, Functional Module Connectivity Map (FMCM): A Framework for Searching Repurposed Drug Compounds for Systems Treatment of Cancer and an application to Colorectal Adenocarcinoma (* Co-corresponding Author), PLOS ONE, 2014, 9(1): e86299
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    7. Huang HN, Chen SY, Hwang SM, Yu CC, Su M-W, Mai W, Wang, HW, Cheng WC, Schuyler SC, Ma N, Lu FL, Lu J, miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation, Stem Cell Research, 2014,12(2):338-353  
    8. Lin CH, Wu JC, Chiou BH, Chen CH, Ma N, Chang CY, Tsen YK and Chen SC, MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells, Toxicology, 2014, 322:69-77
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    9. Liu SM, Lu J, Lee, HC, Chung FH, and Ma N*, miR-524-5p suppresses growth of oncogenic BRAF melanoma by targeting BRAF and ERK2, Oncotarget , 2014, 5(19):9444-59
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    10. Lo W-S, Liu SM, Wang S-C, Lin H-P, Ma N*, Huang H-Yand Shieh F-K*, A green and facile approach to obtain 100 nm zeolitic imidazolate framework-90 (ZIF-90) particles via leveraging viscosity effects (* Co-corresponding Author), RSC Advances 2014, 4:52883-86
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    會議論文摘要
     
    1. Ma N#, Lai C-H#, Chung C-H, Yang J-M, Hsu K-Cheng, Chen C-Y, Chung T-S, Li S, Ho C-T, Pan M-H*, 5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)12-0-tetra decanoyl phorbol-13-acetate (TPA)-induced skin tumorigenesis , (# Co-First Author) , Journal of Functional Foods 2014, 11:528-537  

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